Table 3

 Distribution of UGT1A7 genotypes in patients with pancreatic diseases and healthy controls

Czech RepublicGermanyNetherlands
GenotypeACP (n = 38)ICP/HP (n = 55)CO (n = 319)ACP (n = 148)ICP/HP (n = 136)AP (n = 153)PC (n = 201)CO (n = 432)Alc CO (n = 30)ACP (n = 77)ICP/HP (n = 59)CO (n = 275)Alc CO (n = 93)
UGT1A7
    *1/*14 (11%)9 (16%)38 (12%)22 (15%)16 (12%)20 (13%)25 (12%)56 (13%)0 (0%)10 (13%)12 (20%)38 (14%)17 (18%)
    *1/*24 (11%)10 (18%)60 (19%)18 (12%)23 (16%)19 (12%)37 (18%)63 (15%)5 (17%)12 (16%)10 (17%)45 (16%)22 (24%)
    *1/*312 (32%)15 (27%)88 (28%)43 (29%)49 (36%)44 (29%)45 (22%)104 (24%)10 (33%)25 (33%)13 (22%)80 (29%)23 (25%)
    *1/*100 (0%)0 (0%)3 (0.9%)0 (0%)1 (0.7%)0 (0%)1 (0.5%)2 (0.5%)0 (0%)1 (1.3%)1 (1.7%)2 (0.7%)0 (0%)
    *2/*24 (11%)6 (11%)12 (4%)13 (9%)8 (6%)11 (7%)4 (2%)33 (8%)2 (7%)3 (4%)5 (8%)19 (7%)3 (3%)
    *2/*37 (18%)3 (6%)59 (19%)28 (19%)19 (14%)32 (21%)55 (27%)79 (18%)7 (23%)13 (17%)6 (10%)42 (15%)13 (14%)
    *2/*100 (0%)1 (2%)2 (0.6%)2 (1.4%)0 (0%)0 (0%)2 (1%)2 (0.5%)0 (0%)0 (0%)0 (0%)1 (1%)0 (0%)
    *3/*37 (18%)11 (20%)50 (16%)22 (15%)20 (15%)25 (16%)28 (14%)90 (21%)6 (20%)11 (14%)11 (19%)48 (18%)15 (16%)
    *3/*100 (0%)0 (0%)7 (2%)0 (0%)0 (0%)2 (1.3%)4 (2%)3 (0.7%)0 (0%)2 (2.6%)1 (1.7%)0 (0%)0 (0%)
    *3/*110 (0%)0 (0%)0 (0%)0 (0%)0 (0%)0 (0%)0 (0%)0 (0%)0 (0%)0 (0%)0 (0%)0 (0%)0 (0%)
SwitzerlandAll countries
GenotypeACP (n = 55)ICP/HP (n = 16)PC (n = 35)CO (n = 383)ACP (n = 318)ICP/HP (n = 266)AP (n = 153)PC (n = 236)CO (n = 1409)Alc CO (n = 123)
OR1 is given for the *3/*3 v *x/*x genotypes; OR2 is given for *3/*x v *x/*x genotypes (x = 1, 2, 10, or 11).
ACP, alcoholic chronic pancreatitis; Alc CO, alcoholic control subjects; AP, acute pancreatitis; CI, confidence interval; CO, healthy control subjects; ICP/HP, idiopathic chronic pancreatitis/hereditary chronic pancreatitis; OR, odds ratio adjusted for age, sex, and country of origin; PC, pancreatic adenocarcinoma.
UGT1A7
    *1/*110 (18%)1 (6%)1 (3%)47 (12%)46 (14%)38 (14%)20 (13%)26 (11%)179 (13%)17 (14%)
    *1/*29 (16%)3 (19%)6 (17%)55 (14%)43 (14%)46 (17%)19 (12%)43 (18%)223 (16%)27 (22%)
    *1/*311 (20%)6 (39%)9 (26%)126 (33%)91 (29%)83 (31%)44 (29%)54 (23%)398 (28%)33 (27%)
    *1/*101 (1.8%)0 (0%)1 (3%)2 (0.5%)2 (0.6%)2 (0.8%)0 (0%)2 (0.8%)9 (0.6%)0 (0%)
    *2/*24 (7%)0 (0%)4 (11%)23 (6%)24 (8%)19 (7%)11 (7%)8 (3%)87 (6%)5 (4%)
    *2/*314 (26%)4 (25%)9 (26%)65 (17%)62 (19%)32 (12%)32 (21%)64 (27%)245 (17%)20 (16%)
    *2/*100 (0%)0 (0%)0 (0%)2 (0.5%)2 (0.6%)1 (0.4%)0 (0%)2 (0.8%)7 (0.5%)0 (0%)
    *3/*36 (11%)2 (13%)5 (14%)58 (15%)46 (14%)44 (17%)25 (16%)33 (14%)246 (17%)21 (17%)
    *3/*100 (0%)0 (0%)0 (0%)4 (1%)2 (0.6%)1 (0.4%)2 (1.3%)4 (1.7%)14 (1%)0 (0%)
    *3/*110 (0%)0 (0%)0 (0%)1 (0.3%)0 (0%)0 (0%)0 (0%)0 (0%)1 (0.1%)0 (0%)
OR10.730.910.950.710.900.93
95% CI0.48 to 1.120.57 to 1.450.54 to 1.680.44 to 1.150.38 to 2.110.51 to 1.68
OR21.110.951.291.251.600.95
95% CI0.81 to 1.500.67 to 1.360.84 to 1.980.89 to 1.750.86 to 2.970.60 to 1.52