Multivariate logistic maximum likelihood estimates of segregation models for inheritance of non-syndromic hereditary hearing impairment
| Multifactorial only | Multifactorial+commingled | Multifactorial+Mendelian | Multifactorial+free τ’s | Multifactorial+dominant | Multifactorial+recessive | |
|---|---|---|---|---|---|---|
| Test H01: no major gene effect, χ2 = 4.57, df = 3, p = 0.116 | ||||||
| Test H02: no transmission of major gene effect, χ2 = 10.63, df = 3, p = 0.014 | ||||||
| Test H03: Mendelian transmission, χ2 = 16.26, df = 3, p = 0.001 | ||||||
| Test H04: Mendelian transmission and dominant inheritance, χ2 = 3.83, df = 1, p = 0.050 | ||||||
| Test H05: Mendelian transmission and recessive inheritance, χ2 = 4.98, df = 1, p = 0.026 | ||||||
| *This parameter estimator did not converge well, but the hypotheses can still be tested by comparing the models. | ||||||
| q A | (1.0) | 1.0 | 1.0 | 0.85 | 1.0 | 1.0 |
| τ AA | ... | ... | (1.0) | 1.0 | (1.0) | (1.0) |
| τ AB | ... | ... | (0.5) | 0.0 | (0.5) | (0.5) |
| τ BB | ... | ... | (0.0) | 0.0 | (0.0) | (0.0) |
| Susc AA | −1.64 | −1.75 | −1.62 | * | −1.65 | −1.67 |
| Susc AB | ... | −1.75 | −1.53 | −1.61 | −1.65 | −1.67 |
| Susc BB | ... | −1.75 | −1.35 | −1.61 | −1.60 | −1.67 |
| ρresid | 7.37 | 7.93 | 6.12 | 7.21 | 7.15 | 7.49 |
| -2LnL | 83.41 | 82.35 | 87.98 | 71.72 | 84.15 | 83.00 |
| Akaike’s AIC | 87.41 | 90.35 | 95.98 | 83.72 | 90.15 | 91.00 |