Frequency of the G2019S mutation according to familial aggregation
| Proband category | n (%) | Male/female | Onset (years) (mean (SD)) | Range | G2019S | % |
|---|---|---|---|---|---|---|
| *p<0.002 v the frequency among the 452 sporadic probands (Fisher exact test). | ||||||
| †p<0.025: frequency in familial v sporadic early onset probands. | ||||||
| ‡p = 0.05: frequency in familial v sporadic late onset probands. | ||||||
| §p<0.001 v the frequency among the 452 sporadic probands. | ||||||
| NSNo significant difference compared with the frequency among the 452 sporadic probands. | ||||||
| None of the differences between early onset and late onset groups (familial, sporadic, or all) was statistically significant. | ||||||
| PD, Parkinson’s disease. | ||||||
| All probands (early and late onset) | 629 (100%) | 369/260 | 52.7 (10.9) | 23 to 82 | 13 | 2.1% |
| All familial probands (1st, 2nd, 3rd degree affected relatives) | 177 (28.1%) | 103/74 | 52.6 (10.9) | 23 to 82 | 9 | 5.1%* |
| All sporadic probands | 452 (71.9%) | 266/186 | 52.7 (11.0) | 23 to 80 | 4 | 0.9% |
| All early onset probands | 230 (100%) | 149/81 | 40.8 (5.6) | 23 to 49 | 7 | 3.0% |
| Familial early onset | 68 (29.6%) | 43/25 | 41.5 (5.5) | 23 to 49 | 5 | 7.4%† |
| Sporadic early onset | 162 (70.4%) | 106/56 | 40.6 (5.7) | 23 to 49 | 2 | 1.2% |
| All late onset probands | 399 (100%) | 220/179 | 59.5 (6.6) | 50 to 82 | 6 | 1.5% |
| Familial late onset | 109 (27.3%) | 60/49 | 59.6 (6.9) | 50 to 82 | 4 | 3.7%‡ |
| Sporadic late onset | 290 (72.7%) | 160/130 | 59.4 (6.5) | 50 to 80 | 2 | 0.7% |
| Probands with “dominant” PD (1st or 2nd degree affected relatives) | 114 | 68/46 | 50.1 (10.7) | 23 to 74 | 8 | 7.0%§ |
| Probands with one affected parent | 69 | 42/27 | 51.0 (9.7) | 23 to 71 | 6 | 8.7%§ |
| Probands with affected 2nd degree relative only | 42 | 24/18 | 49.2 (11.7) | 32 to 74 | 2 | 4.8%NS |
| Probands with affected siblings and 2nd degree relative | 3 | 2/1 | 41.0 (15.6) | 32 to 59 | 0 | – |
| Probands with affected siblings only | 49 | 27/22 | 56.9 (10.5) | 36 to 82 | 1 | 2.0%NS |
| Probands with affected 3rd degree relative only | 14 | 7/7 | 58.1 (6.9) | 57 to 65 | 0 | – |