Table 1

Sex specific genotype frequencies and fitness estimates

	Country of origin	NN	NH	HH	Total	Fitness NN	Fitness HH	Allele frequency N
Healey^1–⁶ are the data published in Healey et al.¹
Ishitobi refers to the data published in Ishitobi et al.⁶
Auranen^1,² are the controls published in Auranen et al.³
The fitness is relative to genotype NH and is computed separately for each sex specific group.
Italics indicate which data came from the original first report.
Females
*Healey* ¹	UK	138	115	13	266	0.86	0.63	0.73
*Healey* ²	UK	631	493	77	1201	0.94	0.84	0.73
*Healey* ³	UK	124	94	10	228	0.88	0.64	0.75
*Healey* ⁴	Germany	433	373	60	866	0.92	0.81	0.72
*Healey* ⁵	Finland	277	152	24	453	1.03	1.11	0.77
*Healey* ⁶	UK	590	485	75	1150	0.93	0.81	0.72
Blood donors	UK	192	172	25	389	0.89	0.73	0.71
Colon cancer controls	UK	98	72	18	188	1.10	1.24	0.71
Mammography screening control women	UK	466	410	81	957	0.97	0.93	0.70
Ishitobi	Japan	95	56	3	154	0.86	0.43	0.80
Auranen ¹	Australia	139	123	20	282	0.92	0.80	0.71
Auranen ²	Australia	439	322	54	815	0.98	0.94	0.74
Males
*Healey* ⁶	UK	644	435	116	1195	1.15	1.38	0.72
Blood donors	UK	381	329	51	761	0.91	0.78	0.72
Colon cancer controls	UK	115	95	21	231	1.02	1.05	0.70