Functional characterisation of missense mutations
| Aggregation | Invasion | ||
|---|---|---|---|
| Particle diameter (μm) T0 | Particle diameter (μm) T30 | Invasion index (%) | |
| *A heterogeneous cell population characteristic of cells transfected with the empty vector. | |||
| Mock cells* | 16.52 | 19.25 | 10.8±1.2 |
| Wild type | 17.95 | 1067.00 | 1.2±0.2 |
| A298T | 21.60 | 26.21 | 13.5±0.8 |
| W409R | 20.00 | 32.21 | 22.05±0.7 |
| R732Q | 22.08 | 29.22 | 13.2±1.1 |