Unclassified variants in BRCA1 that we find likely to be neutral or of little clinical significance
| Missense variant | Grantham chemical difference33 | highest cross species chemical difference |
|---|---|---|
| I15L | 5 | matches Mouse |
| I31M | 10 | matches Xenopus |
| I42V | 29 | matches Chicken |
| I124V | 29 | matches Chicken |
| Q155E | 29 | matches Xenopus |
| R170Q | 43 | matches Mouse |
| R213G | 125 | matches Mouse |
| A221S | 99 | matches Xenopus |
| R252H | 29 | matches Mouse |
| G275D | 94 | matches Xenopus |
| T276R | 71 | matches Tetraodon |
| R332Q | 43 | matches Mouse |
| K408E | 56 | matches Mouse |
| D411N | 23 | matches Tetraodon |
| N417S | 46 | matches Chicken |
| I456T | 89 | matches Chimpanzee |
| F486L | 22 | matches Xenopus |
| R496H | 29 | matches Dog |
| R504H | 29 | matches Dog |
| T539M | 81 | matches Chimpanzee |
| I571T | 89 | matches Mouse |
| V627I | 29 | matches Mouse |
| S628R | 110 | matches Xenopus |
| S632N | 46 | matches Dog |
| P633S | 74 | matches Chicken |
| H662R | 29 | matches Chicken |
| Q804H | 24 | matches Chicken |
| A807S | 99 | matches Chicken |
| G890R | 125 | matches Chimpanzee |
| G890V | 109 | matches Mouse |
| I925L | 5 | matches Xenopus |
| M1014V | 21 | matches Mouse |
| I1019V | 29 | matches Chicken |
| L1086S | 145 | matches Chicken |
| V1088D | 152 | matches Tetraodon |
| V1181I | 29 | matches Mouse |
| R1203Q | 43 | matches Dog |
| G1205R | 125 | matches Chicken |
| E1219D | 45 | matches Chicken |
| T1249S | 58 | matches Xenopus |
| E1250K | 56 | matches Xenopus |
| A1293V | 99 | matches Chicken |
| E1346K | 56 | matches Xenopus |
| T1349P | 38 | matches Dog |
| C1372Y | 194 | matches Mouse |
| H1402Y | 83 | matches Mouse |
| I1405V | 29 | matches Tetraodon |
| T1485I | 89 | matches Xenopus |
| Y1522C | 194 | matches Dog |
| V1534M | 21 | matches Dog |
| D1546N | 23 | matches Mouse |
| R1589H | 29 | matches Chimpanzee |
| M1628V | 21 | matches Mouse |
| A1669S | 99 | matches Xenopus |
| F1695L | 22 | matches Chicken |
| R1726G | 125 | matches Chicken |
| L87V | 32 | 113 |
| L204F | 22 | 138 |
| D232N | 23 | 126 |
| H239R | 29 | 100 |
| L246V | 32 | 96 |
| V271M | 21 | 152 |
| M297L | 15 | 126 |
| M297I | 10 | 126 |
| A322P | 27 | 126 |
| D369N | 23 | 108 |
| I379M | 10 | 89 |
| D411E | 29 | 98 |
| S454N | 46 | 144 |
| H476R | 29 | 94 |
| K503R | 26 | 95 |
| M658I | 10 | 101 |
| L668F | 22 | 138 |
| N723D | 23 | 91 |
| R728K | 26 | 112 |
| V788I | 29 | 124 |
| H816R | 29 | 115 |
| I917M | 10 | 142 |
| M1008I | 10 | 142 |
| M1008V | 21 | 142 |
| R1028H | 29 | 103 |
| S1101N | 46 | 155 |
| D1152N | 23 | 94 |
| V1247I | 29 | 133 |
| I1275V | 29 | 102 |
| M1361L | 15 | 101 |
| V1378I | 29 | 96 |
| K1487R | 26 | 127 |
| I1529V | 29 | 89 |
| D1778N | 23 | 126 |
| A1843P | 27 | 99 |