Unclassified variants in BRCA1 that we find likely to be deleterious
| Missense variant | Grantham chemical difference33 | Highest cross species chemical difference |
|---|---|---|
| I15T | 89 | 5 |
| L28P | 98 | fully conserved |
| T37R | 71 | fully conserved |
| K38N | 94 | fully conserved |
| K45T | 78 | 26 |
| K45N | 94 | 26 |
| I68K | 102 | 29 |
| S72R | 110 | fully conserved |
| D96N | 23 | fully conserved |
| F461L | 22 | fully conserved |
| I845T | 89 | 29 |
| F861C | 205 | fully conserved |
| R866C | 180 | fully conserved |
| P1150S | 74 | fully conserved |
| P1238L | 103 | fully conserved |
| P1238R | 98 | fully conserved |
| M1400V | 21 | fully conserved |
| L1407P | 98 | fully conserved |
| S1655F | 155 | fully conserved |
| T1685A | 58 | fully conserved |
| T1685I | 89 | fully conserved |
| V1688del | not applicable | 29 |
| M1689R | 91 | 10 |
| V1696L | 32 | fully conserved |
| R1699L | 102 | fully conserved |
| R1699Q | 54 | fully conserved |
| T1700A | 58 | fully conserved |
| G1706A | 59 | fully conserved |
| G1706E | 98 | fully conserved |
| S1715C | 112 | fully conserved |
| S1715N | 46 | fully conserved |
| S1715R | 110 | fully conserved |
| W1718S | 177 | fully conserved |
| V1736A | 64 | fully conserved |
| G1738R | 125 | fully conserved |
| G1738E | 98 | fully conserved |
| G1738del | NA | fully conserved |
| D1739E | 45 | fully conserved |
| H1746N | 68 | fully conserved |
| R1751P | 103 | 26 |
| I1766S | 142 | 29 |
| T1773S | 58 | fully conserved |
| L1780P | 98 | 15 |
| M1783T | 81 | 10 |
| C1787S | 112 | fully conserved |
| G1788D | 94 | fully conserved |
| G1788V | 109 | fully conserved |
| Q1811R | 54 | fully conserved |
| W1837G | 184 | fully conserved |
| W1837R | 101 | fully conserved |
| S1841N | 46 | fully conserved |
| Y1853C | 205 | fully conserved |