Table 1

 Number of expected and observed positions with different numbers of missense changes

Substitutions per position0123456Totalχ2Rate constant*
*Average amino acid substitution rate constants are given in substitutions/position/year. Multiplying these rates by 1730×106 years will result in the substitution frequencies given in the text.
Observed 137.0230.0422.0624.0376.074.00.01863
Model 1 Expected 36.6239.1584.6647.5307.846.80.71863383.62.3×10−9
Model 2 Expected 152.8160.1480.3644.3362.062.41.1186349.7
    (Class 1) 133.01330.0
    (Class 3) 19.8160.1480.3644.3362.062.41.117302.6×10−9
Model 3 Expected 139.4225.5431.5610.5382.772.41.318632.3
    (Class 2) 127.1111.136.85.70.40.00.02810.5×10−9
    (Class 3) 12.3114.4394.7604.8382.372.41.315822.8×10−9