Table 3

Polymorphisms of the PRF1 gene

ExonNucleotide changeAmino acid effectAllele frequency
2272 C→TA91V7/202 (3%)
368 G→AR123H1/202 (0.5%)
435 G→AV145V6/202 (3%)
462 A→GA154A6/202 (3%)
519 G→AT173T1/202 (0.5%)
3755 A→GN252S5/202 (2%)
822 C→TA274A30/202 (15%)
900 C→TH300H136/202 (67%)