Table 3

Significant associations between coronary heart disease or myocardial infarction and single nucleotide polymorphisms in replication genes

Gene (polymorphism)GenotypeRandom populationCoronary heart disease casesMyocardial infarction casesCoronary heart disease adjusted odds ratio (95% confidence interval)p coronary heart diseasemyocardial infarction adjusted odds ratio (95% confidence interval)p myocardial infarctionD′*
*Measure of linkage disequilibrium between the polymorphism listed and the polymorphism with a prior association with coronary heart disease or myocardial infarction in other studies. N/A, not applicable, indicates this is the exact polymorphism with a prior association; unknown, indicates that linkage disequilibrium could not be measured since the prior polymorphism was not evaluated in our study.
APOE (APOE_1)CC51292.92 (0.90, 9.45)0.034.63 (1.38, 15.6)0.04N/A
CT9691421.54 (1.05, 2.28)1.23 (0.76, 1.99)
TT3102201251.001.00
ACE (DCP1_1)GG7878430.87 (0.55, 1.38)0.010.91 (0.53, 1.56)0.02unknown
AG185124640.58 (0.39, 0.85)0.53 (0.33, 0.85)
AA137130721.001.00
F7 (F7_2)AA41373.88 (1.19, 12.6)0.065.05 (1.29, 19.8)0.04N/A
AG8268401.20 (0.79, 1.82)1.34 (0.82, 2.20)
GG3122431301.001.00
FGB (FGB_1)TT19540.43 (0.14, 1.27)0.040.65 (0.20, 2.14)0.250.99
CT13383470.66 (0.46, 0.97)0.70 (0.45, 1.09)
CC2542401251.001.00
FGB (FGB_2)AA19540.43 (0.12, 1.28)0.020.65 (0.20, 2.15)0.201.00
AG13778440.63 (0.43, 0.92)0.67 (0.43, 1.06)
GG2552391241.001.00
FGB (FGB_3)CC20650.49 (0.18, 1.36)0.040.76 (0.25, 2.31)0.23N/A
CT13782460.64 (0.44, 0.93)0.68 (0.43, 1.06)
TT2532391251.001.00
GP1BA (GP1BA_1)TT1445.31 (0.56, 50.6)0.0410.2 (1.08, 96.1)0.05N/A
CT4453241.69 (1.03, 2.77)1.61 (0.87, 2.96)
CC3372681501.001.00
IL1RN (IL1RN_3)CC3122131.45 (0.75, 2.80)0.031.51 (0.70, 3.27)0.37unknown
CT148139691.61 (1.12, 2.33)1.31 (0.84, 2.03)
TT201133771.001.00
LRP1 (LRP1_3)TT4021110.89 (0.47, 1.69)0.031.06 (0.48, 2.34)0.030.99
CT172157851.57 (1.09, 2.26)1.82 (1.16, 2.87)
CC189115571.001.00
MTHFR (MTHFR_1)TT4647311.69 (1.01, 2.83)0.102.41 (1.33, 4.38)0.01N/A
CT172115650.97 (0.67, 1.40)1.07 (0.68, 1.67)
CC191151731.001.00
SELP (SELP_3)AA814113.82 (1.43, 10.2)0.015.31 (1.87, 15.1)0.005−0.43
AG90100541.38 (0.93, 2.04)1.40 (0.87, 2.25)
GG2702071081.001.00
THPO (THPO_1)GG7955330.52 (0.31, 0.89)0.010.64 (0.34, 1.22)0.19unknown
AG176146840.55 (0.36, 0.85)0.62 (0.37, 1.05)
AA7587421.001.00