Summary of localisation of activated Akt and Akt isoforms in 38 thyroid cancer samples
| pAkt | Akt 1 | Akt 2 | Akt 3 | |||||
|---|---|---|---|---|---|---|---|---|
| Nuc | Cyto | Nuc | Cyto | Nuc | Cyto | Nuc | Cyto | |
| *In regions of invasion, nuclear pAkt and Akt 1 were identified. | ||||||||
| †In regions of invasion (n = 8) nuclear immunoactive pAkt and Akt 1 (but not Akt 2) were demonstrated and cytoplasmic pAkt, Akt 1, and Akt 2 were maintained. | ||||||||
| Note that some tumours displayed both nuclear and cytoplasmic staining while others displayed only one type of staining. | ||||||||
| FA (typical) (n = 3) | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 |
| FA (atypical) (n = 10) | 6 | 1 | 6 | 0 | 6 | 6 | 0 | 3 |
| FC (n = 11) | 7* | 8 | 7* | 9 | 1 | 11 | 0 | 7 |
| PC (n = 14) | 2† | 10 | 2† | 10 | 2 | 7 | 0 | 0 |