Linkage homogeneity testing by excess allele sharing at 2p11–q12
| Chromosome | “Chr2_linked” (n = 84) | “Chr2_unlinked” (n = 115) | χ2* (empirical p value) |
|---|---|---|---|
| *χ2 statistic for homogeneity of linkage among the two subgroups. Likelihood for the combined sample in table 2. | |||
| †Proportion of alleles shared IBD by affected siblings. | |||
| IBD, identical by descent. | |||
| Chromosome 5 | |||
| MLS (%IBD) | 0.81 (58) | 2.19 (61) | 8.98 (0.046) |
| Location (cM) (marker) | 133 (D5S471) | 78 (D5S647) | |
| Chromosome 6 | |||
| MLS (%IBD) | 0.69 (57) | 0.86 (57) | 0.64 (>0.50) |
| Location (cM) (marker) | 92 (D6S460) | 76 (D6S257) | |
| Chromosome 7 | |||
| MLS (%IBD) | 0.72 (58) | 1.01 (57) | 1.01 (>0.50) |
| Location (cM) (marker) | 133 (D7S486) | 5 (D7S531) | |
| Chromosome 11 | |||
| MLS (%IBD†) | 2.08 (61) | 1.07 (59) | 7.14 (0.13) |
| Location (cM) (marker) | 77 (D11S937) | 127 (D11S4151) | |
| Chromosome 19 | |||
| MLS (%IBD) | 0.46 (56) | 0.60 (56) | 0.05 (>0.50) |
| Location (cM) (marker) | 73 (D19S902) | 73 (D19S902) | |