Table 2

Clinical and molecular data of our panel of pheochromocytomas

ID SDHD SDHB RET VHL ChangeFreq (%)AgeSexLoc/multSizeMal/invFollow up/met
Affected exon is designed with a E followed by the number of the exon.
SDHB polymorphisms were named according to GenBank accession number: AL049569.
Freq., frequency in control population; Loc/m, location/multicentrity; E-A, paraganglioma extra-adrenal abdominal; Mal/inv, status of malignancy/invasion; met, metastasis.
Follow up is stated in months.
*Family antecedents; †deceased; ‡this patient had suffered three recurrences of the same tumour.
8E3p.Ala90Thr45F2×10×1.472/no
11E4p.Gly148Gly63M748/yes
13E3p.Ser68Ser2.854F13×13×8120/no
18†E2p.Glu42Ala76F3.7
19E2p.His30His60F108/no
26E3p.Ser68Ser2.881F5×1.527/no
27E1, E3p.Gly12Ser, p.Ser68Ser2.560F3.519/no
3*E5g.129586_7ins CTTCTT3.535F6×4.5×3.524/no
17E5p.Ser163Pro2.361M4.5Inv
32‡E6p.Ser195del67F
33*E2g.112759G→A3.319FMal
2E10p.Cys611Phe58F12×8×842/no
22*E11p.Cys634Tyr35M2.5Inv42/no
31E16p.Met918Thr36F
159F11×7.5×6
459M4.5×4.5×4.512/no
532M15×12×1024/no
623F3.548/no
763F17×14×11
924M4.9
10†M6MalMet
1242F5×4.5×3
1473M9×848/no
1561M4.5
16*14FE-A6×5×436/no
2038FNo
2126MNo
2364M10×6×5
2476M4×3×2
2523F213/no
2841M8.312/no
2920FE-A/mut4×3×2Inv49/no
3056F4.8×3.8×1.2
34372.9×2.5×2.4Inv