Distribution of APOE ε2, ε 3, and ε 4 alleles in the Gambia
| Subjects* | Severe malaria | Cerebral malaria† | Severe malarial anaemia† | Severe anaemia + cerebral malaria† | Mild malaria | Controls | Total | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| *Percentages within each disease or control group are given in parentheses. | ||||||||||||||
| †Children (24) with severe hypoglycaemia only were excluded from this analysis. | ||||||||||||||
| ‡3×2 χ2 test (df = 2) for comparison with the control group. | ||||||||||||||
| §3×2 χ2 test (df = 2) for comparison with the mild malaria group. | ||||||||||||||
| ¶6×2 χ2 test (df = 5) for comparison with the control group. | ||||||||||||||
| **6×2 χ2 test (df = 5) for comparison with the mild malaria group. | ||||||||||||||
| (A) Alleles | ||||||||||||||
| Total | 1060 | 642 | 272 | 98 | 676 | 1120 | 2856 | |||||||
| ϵ2 | 134 | (12.6) | 80 | (12.5) | 41 | (15.1) | 7 | (7.1) | 78 | (11.5) | 155 | (13.8) | 367 | (12.8) |
| ϵ3 | 682 | (64.3) | 416 | (64.8) | 170 | (62.5) | 67 | (68.4) | 452 | (66.9) | 705 | (62.9) | 1839 | (64.4) |
| ϵ4 | 244 | (23.0) | 146 | (22.7) | 61 | (22.4) | 24 | (24.5) | 146 | (21.6) | 260 | (23.2) | 650 | (22.8) |
| χ2‡ | 0.76 | 0.84 | 0.30 | 3.52 | 3.21 | – | – | |||||||
| P | 0.68 | 0.66 | 0.86 | 0.17 | 0.20 | – | – | |||||||
| χ2§ | 1.19 | 0.64 | 2.55 | 1.86 | – | – | – | |||||||
| p | 0.55 | 0.72 | 0.28 | 0.39 | – | – | – | |||||||
| (B) Genotypes | ||||||||||||||
| Total | 530 | 321 | 136 | 49 | 338 | 560 | 1428 | |||||||
| ϵ2/ϵ2 | 6 | (1.1) | 3 | (0.9) | 1 | (0.7) | 1 | (2.0) | 2 | (0.6) | 9 | (1.6) | 17 | (1.2) |
| ϵ2/ϵ3 | 86 | (16.2) | 55 | (17.1) | 24 | (17.6) | 4 | (8.2) | 56 | (16.6) | 96 | (17.1) | 238 | (16.7) |
| ϵ2/ϵ4 | 36 | (6.8) | 19 | (5.9) | 15 | (11.0) | 1 | (2.0) | 18 | (5.3) | 41 | (7.3) | 95 | (6.6) |
| ϵ3/ϵ3 | 220 | (41.5) | 134 | (41.7) | 57 | (41.9) | 21 | (42.9) | 152 | (45.0) | 235 | (42.0) | 607 | (42.5) |
| ϵ3/ϵ4 | 156 | (29.4) | 93 | (29.0) | 32 | (23.5) | 21 | (42.9) | 92 | (27.2) | 139 | (24.8) | 387 | (27.1) |
| ϵ4/ϵ4 | 26 | (4.9) | 17 | (5.3) | 7 | (5.1) | 1 | (2.0) | 18 | (5.3) | 40 | (7.1) | 84 | (5.9) |
| χ2¶ | 5.1 | 3.7 | 3.2 | 11.42 | 5.1 | – | – | |||||||
| p | 0.40 | 0.60 | 0.67 | 0.044 | 0.41 | – | – | |||||||
| χ2** | 2.39 | 0.96 | 5.35 | 8.62 | – | – | – | |||||||
| p | 0.79 | 0.97 | 0.38 | 0.13 | – | – | – | |||||||