Comparison of genotype frequencies at candidate SNPs among patients with no or mild versus severe sepsis
| Polymorphism | No or mild sepsis (n = 123) | Severe sepsis(n = 36) | Unadjusted value |
|---|---|---|---|
| Exact p values are presented for unadjusted analysis of allele frequencies between the two groups by χ2 analysis. | |||
| TNF-α −308 G→A transition | |||
| Homozygous G (n = 120) | 100 (83%) | 20 (17%) | 0.002 |
| A-allele carriers (n = 39) | 23 (59%) | 16 (41%) | |
| TLR4 +896 A→G transition | |||
| Homozygous A (n = 141) | 112 (79%) | 29 (21%) | 0.080 |
| G-allele carriers (n = 18) | 11 (61%) | 7 (39%) | |
| IL-6 −174 G→C transversion | |||
| Homozygous G (n = 86) | 69 (80%) | 17 (20%) | 0.347 |
| C-allele carriers (n = 73) | 54 (74%) | 19 (26%) | |
| CD14 −159 C→T transition | |||
| Homozygous C (n = 52) | 36 (69%) | 16 (31%) | 0.095 |
| Heterozygotes (n = 77) | 60 (78%) | 17 (22%) | |
| Homozygous T (n = 30) | 27 (90%) | 3 (10%) | |
| IL-1β −31 T→C transition | |||
| Homozygous T (n = 60) | 48 (80%) | 12 (20%) | 0.206 |
| Heterozygotes (n = 67) | 54 (81%) | 13 (19%) | |
| Homozygous C (n = 32) | 21 (66%) | 11 (34%) | |