Table 1

Demographic data of 98 patients with atypical haemolytic uraemic syndrome

Mutation positiveMutation negativeTotalp Value
p Value indicates statistical differences of mutation-positive v mutation-negative patients.
FFP, fresh frozen plasma; SLE, systemic lupus erymathosus.
Patients (n)1695111
Age at onset of HUS (median)1–59 (29)2–78 (32)1–78 (32)0.074
Sex (M/F)7/936/5943/680.428
Complement activation parameters
Decreased /(elevated) serum C35 / (1)2 / (14)7 / (15)
Decreased /(elevated) factor H0 / (6)0 / (15)0 / (21)
Associated conditions
Familial aHUS2680.342
Drugs (ovulation inhibitors)3 (3)14 (6)17 (9)0.459 (0.120)
Gestation/after childbirth114150.322
Malignant tumours0660.384
Signs of infections211130.593
Other conditions (SLE etc).48120.070
Treatment and outcome
Plasma exchange (FFP alone)7 (1)69 (2)76 (3)0.025 (0.376)
Relapse in genuine kidneys523280.374
Chronic renal failure115160.284
End stage renal failure1369820.350