Patients (n) | 16 | 95 | 111 | — |
Age at onset of HUS (median) | 1–59 (29) | 2–78 (32) | 1–78 (32) | 0.074 |
Sex (M/F) | 7/9 | 36/59 | 43/68 | 0.428 |
Complement activation parameters | | | | |
Decreased /(elevated) serum C3 | 5 / (1) | 2 / (14) | 7 / (15) | — |
Decreased /(elevated) factor H | 0 / (6) | 0 / (15) | 0 / (21) | — |
Associated conditions | | | | |
Familial aHUS | 2 | 6 | 8 | 0.342 |
Drugs (ovulation inhibitors) | 3 (3) | 14 (6) | 17 (9) | 0.459 (0.120) |
Gestation/after childbirth | 1 | 14 | 15 | 0.322 |
Malignant tumours | 0 | 6 | 6 | 0.384 |
Signs of infections | 2 | 11 | 13 | 0.593 |
Other conditions (SLE etc). | 4 | 8 | 12 | 0.070 |
Treatment and outcome | | | | |
Plasma exchange (FFP alone) | 7 (1) | 69 (2) | 76 (3) | 0.025 (0.376) |
Relapse in genuine kidneys | 5 | 23 | 28 | 0.374 |
Chronic renal failure | 1 | 15 | 16 | 0.284 |
End stage renal failure | 13 | 69 | 82 | 0.350 |