Table 5

Comparison between the Brcapro and IC models in the entire dataset and by gene

Gene	Number of families	Number of mutations	IC model			Brcapro model
Gene	Number of families	Number of mutations	Mutations expected	χ²	Log likelihood	Mutations expected	χ²	Log likelihood
*BRCA1* and *BRCA2*
HBC	357	60	62.7	0.14	−204.2	59.3	0.01	−204.8
HBOC	151	57	47.7	2.63	−138.8	41.2	8.31	−149.5
HOC	31	8	6.7	0.31	−16.1	4.0	4.70	−15.7
MBC	29	8	10.7	1.12	−22.7	11.6	1.83	−26.2
Total	568	133	127.9	4.20	−381.7	116.0	14.84	−396.2
*BRCA1*
HBC	357	27	49.0	11.4	−97.2	47.4	10.1	−94.3
HBOC	151	45	41.2	0.5	−102.7	35.8	3.1	−110.4
HOC	31	7	6.3	0.1	−13.2	3.7	3.3	−13.4
MBC	21	1	3.4	2.0	−6.6	3.5	2.2	−8.6
Total	560	80	99.9	14.1	−219.6	90.5	18.8	−226.7
*BRCA2*
HBC	276	33	13.7	28.7	−117.4	11.8	39.5	−121.4
HBOC	131	12	6.6	4.7	−43.1	5.4	8.3	−45.6
HOC	28	1	0.4	1.1	−3.9	0.3	2.0	−2.9
MBC	29	7	5.8	0.3	−18.1	5.9	0.2	−19.0
Total	464	53	26.4	34.8	−182.5	23.5	50.0	−188.9