Table 4

Expected versus observed number of mutations by risk.* Values are numbers (percentages)

ModelNumber of familiesObservedExpectedObserved/expectedχ2
*Probabilities stratified in three groups separately by model, so that families in each group differ across models.
P<0.01
Myriad Tables186 (43)2313.01.88.2
Spanish134 (31)217.82.723.6
Finnish232 (54)329.83.352.1
Yale198 (46)355.56.4162.6
Brcapro203 (47)215.53.844.3
IC182 (43)175.92.921.5
0.1<P<0.4
Myriad Tables200 (47)6046.41.35.2
Spanish213 (50)5145.81.10.7
Finnish133 (31)4228.21.58.6
Yale114 (27)2623.91.10.2
Brcapro101 (24)2221.91.00.0
IC116 (27)2226.10.80.8
P>0.4
Myriad Tables42 (10)2222.61.00.0
Spanish81 (19)3344.20.76.3
Finnish63 (15)3141.10.87.2
Yale116 (27)4468.70.621.8
Brcapro124 (29)6272.60.93.7
IC130 (30)6677.00.93.9