Evolutionary conservation of BBS genes surrounding mutation sites showing local alignment of amino acid sequence A, BBS2. B, BBS4. C, MKKS (the number indicates the position of the missense mutation)
| A | ||
|---|---|---|
| HS, Homo sapiens; MM, Mus musculus; DR, Danio rerio; DM, Drosophila melanogaster; AM, Anopheles gambiae. | ||
| BBS2 | 643 | |
| HS | KTMKS R YMELY | |
| MM | KTMKS R YMELY | |
| DR | RNMKK R YIELY | |
| B | ||
| BBS4 | 46 | 503 |
| HS | LHYIR K DYEAC | EPE P AVESS |
| MM | LHYIR K DYEAC | EPEPE P TVEAS |
| AG | GLYTR K HFEQC | |
| DM | IYFTR R REFTR | |
| C | ||
| MKKS | 181 | 492 |
| HS | ALILR A FLLTI | VANWP D LLSQC |
| MM | ALILK A FLLTI | VGNWS D TLSRC |
| DR | SLITQ A FLYSI | ISSQT E VKHTC |