Distribution of MTHFR genotypes, Hardy-Weinberg expectations, and p value
| Genotype (No) | Observed/expected | |||||||
|---|---|---|---|---|---|---|---|---|
| Area | Sample No | CC | CT | TT | CC | CT | TT | p value, χ2 |
| Europe | ||||||||
| Italy, Sicily | 468 | 138 | 236 | 94 | 1.0 | 1.0 | 1.0 | |
| Italy, Campania | 500 | 172 | 196 | 132 | 1.2 | 0.8 | 1.2 | p <0.05 |
| Italy, Veneto | ||||||||
| Italian whites | 385 | 128 | 198 | 59 | 1.0 | 1.1 | 0.9 | |
| Spain, multicentre | ||||||||
| Spanish whites | 601 | 265 | 265 | 71 | 1.0 | 1.0 | 1.0 | |
| France, Strasbourg | 178 | 72 | 85 | 21 | 1.0 | 1.0 | 0.9 | |
| The Netherlands | 188 | 97 | 79 | 12 | 1.0 | 1.1 | 0.9 | |
| Finland, Helsinki | 545 | 293 | 230 | 22 | 1.0 | 1.1 | 0.6 | p <0.05 |
| Hungary | 378 | 165 | 171 | 42 | 1.0 | 1.0 | 1.0 | |
| Russia | 587 | 312 | 234 | 41 | 1.0 | 1.0 | 1.0 | |
| Middle East | ||||||||
| Israel | 210 | 120 | 72 | 18 | 1.0 | 0.9 | 1.3 | |
| China | ||||||||
| North, Han | 643 | 201 | 315 | 127 | 1.0 | 1.0 | 1.0 | |
| South, Han | 430 | 167 | 228 | 35 | 0.9 | 1.2 | 0.7 | p <0.05 |
| Oceania | ||||||||
| Australia | ||||||||
| Whites | 288 | 146 | 119 | 23 | 1.0 | 1.0 | 1.0 | |
| Americas | ||||||||
| Mexico | 500 | 91 | 248 | 161 | 1.0 | 1.0 | 1.0 | |
| USA, Atlanta | ||||||||
| Whites | 300 | 142 | 126 | 32 | 1.0 | 1.0 | 1.1 | |
| Blacks | 298 | 231 | 59 | 8 | 1.0 | 0.9 | 1.7 | |
| Hispanics | 62 | 22 | 29 | 11 | 1.0 | 1.0 | 1.0 | |
| Asian | 26 | 16 | 9 | 1 | 1.0 | 1.0 | 0.9 | |
| Other, unknown | 100 | 63 | 32 | 5 | 1.0 | 1.0 | 1.1 | |
| Canada, Alberta | ||||||||
| Whites | 240 | 136 | 90 | 14 | 1.0 | 1.0 | 1.0 | |