HNPCC | Colorectal | Colonoscopy every 1–2 years beginning at age 25 | Colonoscopy every 1–3 years beginning at age 25 |
| Endometrial (women only) | Transvaginal ultrasound ± endometrial biopsy every 1 year beginning at age 25–35 | Endometrial ultrasound or biopsy every year beginning at age 35 |
FAP |
People without polyps | Colorectal | Flexible sigmoidoscopy* every 1 year beginning at age 12 | Flexible sigmoidoscopy or colonoscopy every 1–3 years |
| | Flexible sigmoidoscopy* | |
| | Every 1 years, ages 12–25 | |
| | Every 2 years, ages 26–35 | |
| | Every 3 years, ages 36–50 | |
| | After age 50 resume “average risk” screening | |
People with polyps | Upper tract | Upper endoscopy with ampullary biopsy every 6 months to 4 years depending on polyp burden | EGD every 1–5 years |
| Colorectal | Surgical colectomy with continued upper and lower tract surveillance | |
Subtotal colectomy or total colectomy with ileorectal anastomosis | Rectal remnant | Flexible sigmoidoscopy every 6 months–1 year with polypectomies as needed | Flexible sigmoidoscopy every 1 year |
Total colectomy with ileoanal anastomosis | Pouch | Endoscopic surveillance of pouch every 3–5 years (increase frequency if polyps are found) | Flexible sigmoidoscopy every 3–5 years |