Table 4

Cox proportional hazard model to test the significance of clinical covariates and genotypes of the CYP11B2 polymorphism as predictors of renal survival within groups for each gender

Variablep valueHR95% CI
HR, hazard ratio; CI, confidence interval; ACEI/ARB, angiotensin-I converting enzyme inhibitor and/or angiotensin receptor blocker.
Female patients (n=143)
    Urinary protein excretion >1.0 g/day0.01412.5051.203 to 5.217
    Hypertension0.00731.9181.259 to 3.942
    No ACEI/ARB administration0.00743.2251.368 to 7.599
    CC genotype of CYP11B20.00224.2841.686 to 10.881
Male patients (n=128)
    Urinary protein excretion >1.0 g/day0.00364.7681.664 to 13.666
    Hypertension0.00073.6491.725 to 7.718
    No ACEI/ARB administration0.02142.2991.131 to 4.672
    CC genotype of CYP11B20.62690.7880.301 to 2.061