Mutation profile of the MSI target genes in 32 MSI positive sporadic colorectal carcinomas
| Target genes | ||||||
|---|---|---|---|---|---|---|
| Case No | TGFBR2 (A)10 | BAX (G)8 | IGF2R (G)8 | MSH3 (A)8 | MSH6 (C)8 | BHD (C)8 |
| Previously, Shin et al16 reported the status of mutations in five known target genes. wt, wild type. −1/+1, 1 base deletion/1 base insertion. Bold letters = tumours identified as MSI in this study. | ||||||
| 24 | −2/−2 | wt | wt | −1/wt | wt | wt |
| 45 | wt | wt | wt | wt | −1/wt | −2/wt |
| 51 | wt | wt | wt | wt | −1/wt | wt |
| 59 | −1/+1 | wt | wt | wt | −1/wt | +1/wt |
| 66 | −1/−2 | wt | wt | wt | −1/wt | +1/wt |
| 67 | −1/−2 | −1/−1 | wt | −1/wt | wt | wt |
| 68 | −1/+1 | wt | wt | wt | wt | wt |
| 90 | −1/wt | wt | wt | −1/wt | −1/wt | wt |
| 91 | −1/−1 | wt | wt | −1/wt | −1/wt | −1/wt |
| 95 | −2/wt | −1/wt | wt | −1/wt | −1/−1 | −1/wt |
| 102 | −2/+1 | wt | −1/wt | −1/wt | −1/−1 | wt |
| 134 | wt | −1/wt | wt | wt | wt | wt |
| 151 | −1/−2 | −1/wt | wt | wt | wt | wt |
| 153 | −1/−2 | −1/wt | wt | wt | −1/wt | wt |
| 164 | −1/wt | −1/wt | −1/wt | −1/wt | wt | wt |
| 171 | −1/−1 | −1/wt | wt | −1/wt | wt | wt |
| 172 | −1/−2 | −1/wt | +1/wt | −1/wt | wt | wt |
| 193 | −1/wt | −1/wt | wt | wt | wt | wt |
| 206 | −1/wt | −1/wt | −1/wt | wt | wt | wt |
| 222 | −2/−1 | −1/wt | wt | −1/wt | wt | wt |
| 218 | wt | wt | wt | wt | wt | wt |
| 225 | −1/wt | wt | wt | −1/wt | wt | wt |
| 236 | −1/wt | wt | −1/wt | wt | wt | wt |
| 243 | −2/wt | −1/wt | wt | wt | wt | wt |
| 256 | −1/−2 | −1/wt | wt | wt | −1/wt | wt |
| 260 | wt | wt | wt | −1/wt | wt | wt |
| 268 | −1/wt | wt | wt | wt | wt | wt |
| 380 | wt | −1/wt | wt | −1/wt | wt | wt |
| 381 | −1/−1 | wt | wt | wt | wt | wt |
| 408 | −1/wt | −1/wt | wt | −1/wt | wt | wt |
| 411 | −1/wt | wt | wt | wt | −1/wt | wt |
| 444 | −2/wt | −1/wt | wt | wt | wt | wt |
| 26 (81%) | 16 (50%) | 5 (16%) | 14 (44%) | 11 (34%) | 5 (16%) | |