Genotype combinations | All | SPT− | SPT+ | ||||||
---|---|---|---|---|---|---|---|---|---|
IL1A | IL1B | IL1RN | No | % | No | % | No | % | OR (95% CI) |
No=number of patients (in genotype combination)/chromosomes (in haplotypes), CI=confidence intervals. | |||||||||
1.1 | 1.1 | 1.1 | 72 | 18.9 | 43 | 18.2 | 29 | 20.1 | 1.13 (0.670 to 1.910) |
1.2 | 1.1 | 1.1 | 18 | 4.7 | 11 | 4.7 | 7 | 4.9 | 1.05 (0.396 to 2.760) |
1.1 | 1.2 | 1.1 | 3 | 0.8 | 0 | 0.0 | 3 | 2.1 | – |
1.2 | 1.2 | 1.1 | 69 | 18.2 | 51 | 21.6 | 18 | 12.5 | 0.52 (0.289 to 0.928) |
2.2 | 1.2 | 1.1 | 14 | 3.7 | 8 | 3.4 | 6 | 4.2 | 1.24 (0.421 to 3.650) |
1.2 | 2.2 | 1.1 | 2 | 0.5 | 2 | 0.8 | 0 | 0.0 | – |
2.2 | 2.2 | 1.1 | 22 | 5.8 | 14 | 5.9 | 8 | 5.6 | 0.93 (0.381 to 2.280) |
1.1 | 1.1 | 1.2 | 67 | 17.6 | 39 | 16.5 | 28 | 19.4 | 1.22 (0.713 to 2.090) |
1.2 | 1.1 | 1.2 | 19 | 5.0 | 14 | 5.9 | 5 | 3.5 | 0.57 (0.201 to 1.620) |
2.2 | 1.1 | 1.2 | 2 | 0.5 | 2 | 0.8 | 0 | 0.0 | – |
1.1 | 1.2 | 1.2 | 3 | 0.8 | 2 | 0.8 | 1 | 0.7 | 0.82 (0.074 to 9.110) |
1.2 | 1.2 | 1.2 | 46 | 12.1 | 29 | 12.3 | 17 | 11.8 | 0.96 (0.505 to 1.810) |
2.2 | 1.2 | 1.2 | 3 | 0.8 | 3 | 1.3 | 0 | 0.0 | – |
1.1 | 2.2 | 1.2 | 1 | 0.3 | 1 | 0.4 | 0 | 0.0 | – |
1.2 | 2.2 | 1.2 | 1 | 0.3 | 0 | 0.0 | 1 | 0.7 | – |
2.2 | 2.2 | 1.2 | 4 | 1.1 | 3 | 1.3 | 1 | 0.7 | 0.54 (0.056 to 5.270) |
1.1 | 1.1 | 2.2 | 26 | 6.8 | 8 | 3.4 | 18 | 12.5 | 4.07 (1.720 to 9.630) |
1.2 | 1.1 | 2.2 | 7 | 1.8 | 5 | 2.1 | 2 | 1.4 | 0.651 (0.294 to 8.030) |
2.2 | 1.2 | 2.2 | 1 | 0.3 | 1 | 0.4 | 0 | 0.0 | – |
Haplotypes | |||||||||
1 | 1 | 1 | 327 | 41.0 | 206 | 41.8 | 121 | 40.3 | 0.94 (0.701 to 1.260) |
1 | 1 | 2 | 180 | 22.9 | 92 | 18.7 | 88 | 29.3 | 1.80 (1.290 to 2.530) |
2 | 2 | 1 | 180 | 22.8 | 122 | 24.8 | 58 | 19.3 | 0.73 (0.511 to 1.030) |
2 | 1 | 1 | 44 | 5.7 | 27 | 5.4 | 17 | 5.8 | 1.03 (0.554 to 1.930) |
2 | 1 | 2 | 24 | 2.9 | 21 | 4.2 | 3 | 1.0 | 0.227 (0.0670 to 0.766) |
1 | 1 | 3 | 14 | 1.8 | 8 | 1.6 | 6 | 2.0 | 1.23 (0.424 to 3.590) |
2 | 2 | 2 | 10 | 1.2 | 8 | 1.6 | 2 | 0.06 | 0.41 (0.085 to 1.920) |
1 | 2 | 1 | 9 | 1.1 | 5 | 0.9 | 4 | 1.3 | 1.32 (0.351 to 4.940) |