Table 4

Results of ASO hybridisation experiments to determine frequency of M1I, G59S, G247S, and E265X mutations. DNA samples from 75 controls from the GEM study were studied for the presence of each of four previously reported RNASEL mutations. 103 men with prostate cancer and 323 unaffected controls from the FMHS, which is a population based case-control study of prostate cancer in African American men, were also analysed. In each assay, several samples were not amplified sufficiently for this analysis and were removed from the total number of samples assayed

MutationGEMFMHS prostate cancer casesFMHS controls
M1I0/740/920/311
G59S0/750/1030/317
V247M0/750/1020/310
E265X0/720/1020/320