Table 3

Summary of missense and nonsense mutations identified through sequence analysis of 95 men with prostate cancer from 75 PCGP families. All mutations were identified through sequence analysis, and five of the substitutions were previously reported by Carpten et al³

Exon	Primer pair	Amino acid change	Nucleotide substitution	No of affecteds identified with mutation
*Novel mutation in this report.
2	RNASEL2	G59S	G175A	1 (PCGP 1115-02)
2	RNASEL2	I97L	A289C	2 (PCGP 345-02 and 392-02)
2	RNASEL3	V247M	G739A	1 (PCGP 168-01)*
2	RNASEL4	E265X	G793T	1 (PCGP 1115-02)
2	RNASEL5	R462Q	G1385A	Common
4	RNASEL7	D541E	T1623G	Common