Table 3

Known FA protein interactions

Interacting proteinsFunctional significanceReference
FANCA with:
    Alpha spectrin IIScaffold protein involved in repair of interstrand cross links132, 133
    XPFDNA repair endonuclease 134
    SNX5Receptor trafficking between organelles 135
FANCC with:
    GRP94Molecular chaperone 136
    CDC2Cell cycle/apoptosis137, 138
    FAZFTranscription regulator 139
    Hsp70Apoptosis 118
    GSTP1Apoptosis 119
    STAT1Growth/differentiation 140
    p450 reductaseOxygen metabolism 111
FANCD2 with:
    BRCA1DNA damage repair 88
    ATMInduces S phase checkpoint following ionising radiation 15
FANCG with:
    CYP2E1Oxygen metabolism 112