(A) Clinical and (B) pathological responses to neoadjuvant chemotherapy in BRCA1/2 carriers and non-carriers
| A | Clinical complete response | Less than clinical complete response | p value |
|---|---|---|---|
| BRCA1/2 carriers | 10 | 1 | – |
| Non-carriers | |||
| Unmatched | 8 | 19 | 0.0009 |
| Matched* | 2 | 9 | 0.002 |
| B | Pathological complete response | Less than pathological complete response | p value |
|---|---|---|---|
| *Carriers were matched to controls on TNM stage and on closest age (means 44.1 and 44.3 years, p=0.95) and grade. | |||
| †Two carriers who had a clinical complete response were excluded from this analysis because they did not have any further surgery after neoadjuvant chemotherapy. | |||
| BRCA1/2 carriers† | 4 | 5 | – |
| Non-carriers | |||
| Unmatched | 1 | 26 | 0.009 |
| Matched* | 0 | 9 | 0.08 |