TNF −308 and LTA NcoI polymorphisms and environmental exposure to oxidative stress in coal miners
| TNF −308 | LTA NcoI | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 11 | 12 | 22 | 12 or 22 | p value* | 11 | 12 | 22 | p value | |
| *12 or 22 v 11. †Excluding two outliers (43.6 and 45.7 kg/m2). | |||||||||
| No | 158 | 52 | 2 | 54 | 18 | 91 | 101 | ||
| Age (years, mean (SD)) | 46.5 (3.5) | 47.1 (3.5) | 46.5 (2.1) | 47.1 (3.5) | 0.3 | 46.1 (3.3) | 47.2 (3.4) | 46.4 (3.5) | 0.16 |
| Body mass index (mean (SD)) | 27.1 (3.7) | 27.6 (3.1) | 29.2 (3.6) | 27.6 (3.1) | 0.3 | 27.6 (3.1) | 27.2 (3.1) | 27.1 (4.0) | 0.9 |
| 26.8 (3.2)† | 0.12 | 26.8 (3.2)† | 0.5 | ||||||
| Smoking habits (%) | |||||||||
| Non-smokers | 20.3 | 17.3 | 50.0 | 18.5 | 11.1 | 24.2 | 17.8 | ||
| Ex-smokers | 29.1 | 32.7 | 0 | 31.5 | 0.9 | 27.8 | 31.9 | 28.7 | 0.5 |
| Current smokers | 50.6 | 50.0 | 50.0 | 50.0 | 61.1 | 43.9 | 53.5 | ||
| Pack years (mean (SD)) | 17.0 (14.9) | 17.7 (15.2) | 0.1 (0.14) | 17.0 (15.3) | 1.00 | 14.4 (9.3) | 17.0 (17.7) | 17.4 (13.1) | 0.7 |
| Current exposure (%) | |||||||||
| None (retirement) | 24.7 | 21.1 | 50.0 | 22.2 | 16.7 | 26.4 | 23.8 | ||
| Low | 48.7 | 48.1 | 50.0 | 48.2 | 0.9 | 55.6 | 47.2 | 48.5 | 0.9 |
| High | 26.6 | 30.8 | 0 | 29.6 | 27.8 | 26.4 | 27.7 | ||
| Cumulative dust exposure (mg/m3 × y, mean (SD)) | 55.3 (38.8) | 63.4 (48.9) | 49.0 (48.1) | 62.9 (48.5) | 0.3 | 73.6 (35.6) | 60.7 (49.9) | 51.9 (32.7) | 0.08 |