Table 2

Genotype and allele frequencies at the polymorphic locus

	Allele frequencies				Genotype frequencies
Age categories	L	M•S	Odds (95% Cl)†	χ², p value‡	Group I	Group II	Odds (95% Cl)†	χ², p value‡
Group I is the group of genotypes with a class L allele, which includes L/L, L/M, and L/S.
Group II is the group of genotypes without a class L allele, which includes M/M, M/S, and S/S.
†Odds for class L allele in the indicated age category versus those in all other age categories.
‡χ² and p value were calculated for differences among the three age categories.
§Odds for group I in the indicated age category versus those in all other age categories.
^p<0.03, ^p<0.01, ^**p<0.001.
⁺p<0.05, ⁺⁺p<0.02, ⁺⁺⁺p<0.005.
Male				χ²=9.76, p=0.008				χ²=6.91, p=0.032
Younger (<60 y)	27 (23%)	91 (77%)	1.98 (1.19 to 3.29)^**		23 (39%)	36 (61%)	1.90 (1.04 to 3.49)⁺
Older (≥60 to 74 y)	31 (16%)	159 (84%)	1.13 (0.70 to 1.85)		29 (31%)	66 (69%)	1.19 (0.68 to 2.07)
Oldest (≥75 y)	22 (10%)	194 (90%)	0.49 (0.29 to 0.82)^**		22 (20%)	86 (80%)	0.50 (0.28 to 0.89)⁺⁺
Female				χ²=3.78, p=0.15				χ²=2.72, p=0.26
Younger (<60 y)	20 (22%)	70 (78%)	1.24 (0.71 to 2.15)		19 (42%)	26 (58%)	1.35 (0.70 to 2.20)
Older (≥60 to 74 y)	47 (22%)	165 (78%)	1.36 (0.87 to 2.11)		42 (40%)	64 (60%)	1.27 (0.76 to 2.14)
Oldest (≥75 y)	30 (15%)	168 (85%)	0.63 (0.39 to 1.00)		30 (30%)	69 (70%)	0.64 (0.38 to 1.10)
Total				χ²=11.8, p=0.0027				χ²=8.84, p=0.012
Younger (<60 y)	47 (23%)	161 (77%)	1.54 (1.06 to 2.24)^*		42 (40%)	62 (60%)	1.57 (1.01 to 2.44)⁺⁺
Older (≥60 to 74 y)	78 (19%)	324 (81%)	1.27 (0.92 to 1.76)		71 (35%)	130 (65%)	1.26 (0.87 to 1.84)
Oldest (≥75 y)	52 (13%)	362 (87%)	0.56 (0.39 to 0.79)^***		52 (25%)	155 (75%)	0.57 (0.39 to 0.84)⁺⁺⁺