Polymorphisms detected in the ATM gene
| Frequency in the breast cancer patients studied | ||||
|---|---|---|---|---|
| nt change | aa change | With family history | Without family history | Controls |
| 133C>T | Arg45Trp | 1/215 (0.5%) | 0/85 | 0/200 |
| 146C>G | Ser49Cys | 1/215 (0.5%) | 0/85 | 0/200 |
| IVS62+8A>C | None | 5/215 (2.3%) | 2/85 (2.4%) | 4/200 (2%) |