Allele and genotype frequencies at the APOE locus among demented and non-demented CFAS subjects, overall
| Farrer et al6‡ | |||||||
|---|---|---|---|---|---|---|---|
| Controls | Cases | Crude OR (95% CI) | Adjusted* OR (95% CI) | Rubinsztein and Easton7† | Population based | Clinic/necropsy | |
| *Adjusted for age, sex, and years of full time education. | |||||||
| †Pooled estimate OR (95% CI) for Alzheimer’s disease. | |||||||
| ‡Pooled estimate OR (95% CI) for Alzheimer’s disease, adjusted for age and study. | |||||||
| Allele | |||||||
| ε3 | 722 | 246 | 1.0 | 1.0 | 1.0 | ||
| ε2 | 85 | 26 | 0.9 (0.6 to 1.4) | 0.7 (0.4 to 1.2) | 0.7 (0.6 to 0.8) | ||
| ε4 | 125 | 52 | 1.2 (0.9 to 1.7) | 1.5 (1.1 to 2.2) | 3.4 (3.0 to 3.6) | ||
| Genotype | |||||||
| ε3/ε3 | 277 | 97 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| ε2/ε2 | 4 | 3 | 2.1 (0.5 to 9.7) | 0.5 (0.1 to 5.2) | 0.9 (0.4 to 2.0) | 0.9 (0.3 to 2.8) | 0.6 (0.2 to 2.0) |
| ε2/ε3 | 67 | 15 | 0.6 (0.3 to 1.2) | 0.5 (0.2 to 1.2) | 0.6 (0.5 to 0.7) | 0.6 (0.5 to 0.9) | 0.6 (0.5 to 0.8) |
| ε2/ε4 | 10 | 5 | 1.4 (0.5 to 4.3) | 1.7 (0.4 to 6.6) | 1.9 (1.3 to 2.8) | 1.2 (0.8 to 2.0) | 2.6 (1.6 to 4.0) |
| ε3/ε4 | 101 | 37 | 1.0 (0.7 to 1.6) | 1.1 (0.6 to 1.9) | 3.4 (3.0 to 3.9) | 2.7 (2.2 to 3.2) | 3.2 (2.8 to 3.8) |
| ε4/ε4 | 7 | 5 | 2.0 (0.6 to 6.6) | 3.8 (1.0 to 14.0) | 13.3 (9.9 to 17.9) | 12.5 (8.8 to 17.7) | 14.9 (10.8 to 20.6) |