Allele and genotype frequencies at the ACE locus among demented and non-demented CFAS subjects — overall
| Cases (%) | Controls (%) | Crude OR (95% CI) | Adjusted* OR (95% CI) | Narain et al7† | |
|---|---|---|---|---|---|
| *Adjusted for age, sex, years in full time education, and APOE ε4 carrier status (for genotype). | |||||
| †Pooled estimate OR (95% CI) for Alzheimer's disease. | |||||
| Allele | |||||
| D | 103 (43.6) | 428 (49.4) | 1.0 | 1.0 | 1.0 |
| I | 133 (56.4) | 438 (50.6) | 1.3 (0.9 to 1.7) | 1.4 (1.0 to 2.0) | 1.2 (1.1 to 1.3) |
| Genotype | |||||
| DD | 28 (23.7) | 116 (26.8) | 1.0 | 1.0 | 1.0 |
| DI | 47 (39.8) | 196 (45.3) | 1.0 (0.6 to 1.7) | 1.2 (0.6 to 2.2) | 1.3 (1.1 to 1.5) |
| II | 43 (36.4) | 121 (27.9) | 1.5 (0.9 to 2.5) | 1.9 (1.0 to 3.7) | 1.4 (1.1 to 1.6) |