Table 1

Diagnostic criteria for Fraser syndrome

Major criteria
    Cryptophthalmos
    Syndactyly
    Abnormal genitalia
    Sib with Fraser syndrome
Minor criteria
    Congenital malformation of nose
    Congenital malformation of ears
    Congenital malformation of larynx
    Cleft lip +/− palate
    Skeletal defects
    Umbilical hernia
    Renal agenesis
    Mental retardation