Table 1

Chronology of disease among 37 patients with SIOD

Age (years) at detection of
Pedigree NoIUGRDecreased growthRecurrent infectionsRenal diseaseCNS symptomsDeathCause of deathCurrent age (years)
CMV, cytomegalovirus; EBV, Epstein-Barr virus; HSV, herpes simplex virus; IUGR, intrauterine growth retardation; NA, information not available; +, symptom present but age of onset not available.
The data from patient 57, whose case history is presented in this manuscript, are shown in bold.
Families with severe disease
Patients born before 1990
    4a+1.5<3.53.58Renal failure
    4b+2.5NA38Renal failure
    6+3.5+3.55Pulmonary embolism
    9+5810CMV encephalitis
    31+081114Lymphoproliferative disease
    35+0638Renal failure
    57 + 0 0.25 5 8 20.0
Patients born after 1990
    21<591012.9EBV infection
    22+<56814.6CMV infection
    262.5<1<45.258Bone marrow failure
    29+022<34Restrictive lung disease
    30+0555.710HSV pneumonitis
    321.6633.84.5Pulmonary embolism
    33a+01.22.75Bone marrow failure
Families with milder disease
Patients born before 1990
    18b+8812Pulmonary oedema