Intronic mononucleotide repeats were screened from 93 samples of tumour DNA of MSI positive colorectal cancer patients. 0–5.7% of samples were mutated in mononucleotide repeats and the length of an intronic mononucleotide repeat correlated positively with the number of slippages for both G/C and A/T repeats (p=0.0020 and p=0.0012, respectively)
| Intronic repeat | Gene (GenBank accession No) | Mutations |
|---|---|---|
| G/C 6 | LPAP (CD45-binding protein) (X97267) | 0/93=0% |
| G/C 6 | Fast skeletal troponin T (TNNT3) (AF026276) | 0/93=0% |
| G/C 7 | Human blood coagulation factor XII gene (M17466) | 2/93=2.2% |
| G/C 7 | Ciliary neurotrophic factor alpha receptor (HSCNFAR05) | 0/92=0% |
| G/C 8 | CMP-N-acetylneuramini acid hydroxylase (AB009668) | 2/81=2.5% |
| G/C 9 | Regulatory factor 2 of sodium/hydrogen exchanger isoform A3 (AB016243) | 4/84=4.8% |
| A/T 6 | Neurofibromatosis 1 (NF1) (AF004526) | 0/93=0% |
| A/T 6 | DNA topoisomerase II beta (TOP2B) (AF087143) | 0/93=0% |
| A/T 7 | LPAP (CD45-binding prot) (X97267) | 0/93=0% |
| A/T 7 | Leptin receptor (OBR) (U62501) | 0/93=0% |
| A/T 8 | DNA topoisomerase II beta (TOP2B) (AF087143) | 5/93=5.4% |
| A/T 8 | Chemokine receptor (CXCR-4) (AF005058) | 0/93=0% |
| A/T 9 | EWS (AB016208) | 5/88=5.7% |
| A/T 9 | Osteonidogen (AB009814) | 4/93=4.3% |