Table 1

Intronic mononucleotide repeats were screened from 93 samples of tumour DNA of MSI positive colorectal cancer patients. 0–5.7% of samples were mutated in mononucleotide repeats and the length of an intronic mononucleotide repeat correlated positively with the number of slippages for both G/C and A/T repeats (p=0.0020 and p=0.0012, respectively)

Intronic repeatGene (GenBank accession No)Mutations
G/C 6LPAP (CD45-binding protein) (X97267)0/93=0%
G/C 6Fast skeletal troponin T (TNNT3) (AF026276)0/93=0%
G/C 7Human blood coagulation factor XII gene (M17466)2/93=2.2%
G/C 7Ciliary neurotrophic factor alpha receptor (HSCNFAR05)0/92=0%
G/C 8CMP-N-acetylneuramini acid hydroxylase (AB009668)2/81=2.5%
G/C 9Regulatory factor 2 of sodium/hydrogen exchanger isoform A3 (AB016243)4/84=4.8%
A/T 6Neurofibromatosis 1 (NF1) (AF004526)0/93=0%
A/T 6DNA topoisomerase II beta (TOP2B) (AF087143)0/93=0%
A/T 7LPAP (CD45-binding prot) (X97267)0/93=0%
A/T 7Leptin receptor (OBR) (U62501)0/93=0%
A/T 8DNA topoisomerase II beta (TOP2B) (AF087143)5/93=5.4%
A/T 8Chemokine receptor (CXCR-4) (AF005058)0/93=0%
A/T 9EWS (AB016208)5/88=5.7%
A/T 9Osteonidogen (AB009814)4/93=4.3%