Table 1

Cancer risks

RelativeObservedO/E95% confidence interval
(A) Risk of breast cancer in relatives of female probands
Females
All probands, 995 families
    Mother811.921.54 to 2.37
    Sister1842.372.04 to 2.68
    Daughter301.941.32 to 2.75
    1st degree2952.181.95 to 2.43
    2nd degree3911.521.37 to 1.67
    3rd degree3711.521.37 to 1.63
BRCA2 positive probands, 90 families
    Mother205.513.51 to 7.99
    Sister509.026.95 to 11.1
    Daughter66.672.48 to 13.9
    1st degree767.556.04 to 9.03
    2nd degree743.182.50 to 3.87
    3rd degree492.581.93 to 3.36
BRCA2 negative probands, 797 families
    Mother591.611.24 to 2.05
    Sisters1221.791.50 to 2.12
    Daughter191.681.01 to 2.60
    1st degree2001.721.49 to 1.96
    2nd degree2711.361.20 to 1.52
    3rd degree2211.331.16 to 1.50
Males
All probands, 995 families
    1st degree75.042.02 to 10.3
    2nd degree31.100.23 to 3.21
    3rd degree83.201.35 to 6.30
BRCA2 positive probands, 90 families
    1st degree666.724.6 to 143
    2nd degree14.510.14 to 25.1
    3rd degree15.650.16 to 31.2
BRCA2 negative probands, 797 families
    1st degree10.850.02 to 4.73
    2nd degree20.970.12 to 3.50
    3rd degree10.560.01 to 3.12
(B) Risk of prostate cancer in relatives of female probands
All probands, 995 families
    1st degree1561.331.13 to 1.55
    2nd degree2511.221.07 to 1.37
    3rd degree2121.050.91 to 1.19
BRCA2 positive probands, 90 families
    1st degree344.793.27 to 6.32
    2nd degree372.211.57 to 3.02
    3rd degree130.920.49 to 3.12
BRCA2 negative probands, 797 families
    1st degree1101.080.89 to 1.29
    2nd degree1771.150.98 to 1.32
    3rd degree1461.030.86 to 1.20
(C) Risk of ovarian cancer in relatives of female probands
All probands, 995 families
    1st degree461.481.08 to 1.96
    2nd degree671.321.00 to 1.63
    3rd degree520.920.67 to 1.17
BRCA2 positive probands, 90 families
    1st degree135.222.80 to 8.77
    2nd degree153.261.84 to 5.32
    3rd degree81.750.76 to 3.42
BRCA2 negative probands, 797 families
    1st degree311.160.78 to 1.64
    2nd degree441.130.80 to 1.46
    3rd degree360.940.63 to 1.24
(D) Risk of stomach cancer in relatives of breast cancer probands
Females
All probands, 995 families
    1st degree461.100.81 to 1.46
    2nd degree1411.391.17 to 1.61
    3rd degree621.030.77 to 1.29
BRCA2 positive probands, 90 families
    1st degree51.780.57 to 4.10
    2nd degree303.082.09 to 4.34
    3rd degree61.190.44 to 2.57
BRCA2 negative probands, 797 families
    1st degree371.050.74 to 1.44
    2nd degree971.220.98 to 1.46
    3rd degree441.050.74 to 1.35
Males
All probands, 995 families
    1st degree971.210.99 to 1.47
    2nd degree1750.990.85 to 1.13
    3rd degree1170.980.80 to 1.16
BRCA2 positive probands, 90 families
    1st degree132.401.29 to 4.05
    2nd degree341.911.33 to 2.63
    3rd degree151.770.99 to 2.89
BRCA2 negative probands, 797 families
    1st degree731.080.85 to 1.35
    2nd degree1180.880.72 to 1.04
    3rd degree750.870.67 to 1.07
(E) Risk of kidney cancer in relatives of breast cancer probands
Females
All probands, 995 families
    1st degree201.040.64 to 1.62
    2nd degree491.391.00 to 1.78
    3rd degree351.090.73 to 1.45
BRCA2 positive probands, 90 families
    1st degree53.571.15 to 8.22
    2nd degree10.300.01 to 1.67
    3rd degree10.370.01 to 2.05
BRCA2 negative probands, 797 families
    1st degree130.790.41 to 1.35
    2nd degree431.591.12 to 2.07
    3rd degree261.190.73 to 1.65
Males
All probands, 995 families
    1st degree270.960.64 to 1.39
    2nd degree490.970.70 to 1.24
    3rd degree581.140.85 to 1.43
BRCA2 positive probands, 90 families
    1st degree62.841.21 to 6.12
    2nd degree40.870.23 to 2.21
    3rd degree20.550.07 to 1.52
BRCA2 negative probands, 797 families
    1st degree200.830.50 to 1.28
    2nd degree381.000.68 to 1.32
    3rd degree421.180.82 to 1.53
(F) Risk of cancer at all sites in relatives of female probands
Females
All probands, 995 families
    1st degree6711.431.34 to 1.52
    2nd degree10361.211.15 to 1.28
    3rd degree9791.161.09 to 1.23
BRCA2 positive probands, 90 families
    1st degree1083.392.88 to 3.89
    2nd degree1381.831.57 to 2.09
    3rd degree971.461.20 to 2.01
BRCA2 negative probands, 797 families
    1st degree5151.271.17 to 1.37
    2nd degree7751.181.11 to 1.26
    3rd degree6461.121.04 to 1.20
Males
All probands, 995 families
    1st degree6091.241.15 to 1.33
    2nd degree9911.121.06 to 1.18
    3rd degree9011.061.00 to 1.12
BRCA2 positive probands, 90 families
    1st degree872.542.08 to 3.00
    2nd degree1511.931.67 to 2.19
    3rd degree711.180.93 to 1.43
BRCA2 negative probands, 797 families
    1st degree4761.141.05 to 1.23
    2nd degree6961.040.97 to 1.11
    3rd degree6141.040.96 to 1.12