Main clinical features of patients with insulin dependent neonatal diabetes (ND)
| Patients | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clinical features | A | B | C | D | E | F | G | I3 | I4 | J | K | M* | N | O |
| Tr=transient ND; P=permanent ND; na=not available. | ||||||||||||||
| *Patient M developed non-insulin dependent diabetes at 18 years of age with hyperglycaemia controlled by oral sulphonylurea. | ||||||||||||||
| †Duration of insulin therapy in transient ND; d=days, mth=months; T1D=type 1 diabetes in the paternal branch for patients D, I3, and I4 and in the maternal grandparents for patients C and K; T2D=type 2 diabetes in the maternal grandparents for the transient ND patients. | ||||||||||||||
| ‡Case O, is subject O7 of a multiplex family with insulin dependent diabetes appearing before 6 months of age (see pedigree in fig 2[f2]. | ||||||||||||||
| §Congenital birth anomalies degree of severity: (−)=absent, (+)=moderate mild, (++)=marked with a combination of more than two organs affected, details in table 2[t2]. | ||||||||||||||
| Sex | F | F | F | M | F | M | M | F | M | M | M | F | M | M |
| Birth weight (g) | 1670 | 2190 | 2800 | 2600 | 1750 | 1960 | na | 1900 | 2020 | 1840 | 3200 | 1600 | 3160 | 3050 |
| Age at diagnosis | 13 d | 5 d | 2 d | 2 d | 1 d | na | 5 d | 1 d | 1 d | 1 d | 26 d | 6 d | na | 6 mth |
| Diabetes form | Tr | Tr | Tr | P | Tr | Tr | P | P | P | Tr | Tr | Tr | Tr | P |
| Insulin† | 12 d | 5 mth | 2.5 mth | 4 mth | 4.5 mth | 3.5 mth | 13 mth | 5 mth | na | |||||
| Family diabetes history | − | − | T1D | T1D | − | − | − | T1D | T1D | − | T1D | − | − | yes‡ |
| − | T2D | T2D | − | − | − | − | − | − | − | T2D | T2D | T2D | ||
| Congenital birth anomalies§ | − | − | ++ | + | ++ | − | + | ++ | ++ | + | ++ | − | − | − |