Single locus analysis for each of the four SNPs of RET in the different populations studied. The studied populations comprised 247 sporadic PTC patients from Italy (n=100), Portugal (n=95), France (n=26), and Australia (n=26); 319 controls were matched for age, sex, and geographical origin (100 for Italy, 62 for Portugal, 102 for France, and 55 for Australia)
| Frequency† | Odds ratio‡ | |||||||
|---|---|---|---|---|---|---|---|---|
| SNP | PTC | Controls | Model | All† | Italy | Portugal | Australia | France |
| *Significant p value (less than 0.05). | ||||||||
| †Frequency of the rare allele in the pooled population. | ||||||||
| ‡Odds ratio is given for each model: codominant (comparison of allelic frequencies), dominant (heteroygotes and rare homozygotes have the same risk), and recessive (heterozygotes and frequent homozygotes have the same risk), respectively. | ||||||||
| Exon 2 | 0.26 | 0.29 | Codom | 0.83 | 0.70 | 0.78 | 1.31 | 0.72 |
| Dom | 0.73 | 0.54* | 0.68 | 1.19 | 0.71 | |||
| Rec | 0.94 | 0.85 | 1.10 | 0.44 | 2.13 | |||
| Exon 13 | 0.22 | 0.24 | Codom | 1.17 | 1.26 | 1.48 | 0.92 | 1.20 |
| Dom | 1.04 | 1.08 | 1.32 | 0.95 | 0.96 | |||
| Rec | 2.22* | 3.57 | 5.56 | 0.71 | 2.44 | |||
| Exon 14 | 0.05 | 0.06 | Codom | 0.89 | 0.90 | 0.86 | 1.29 | 1.13 |
| Dom | 0.85 | 0.90 | 0.74 | 1.30 | 1.14 | |||
| Rec | – | – | – | – | – | |||
| Exon 15 | 0.19 | 0.19 | Codom | 1.01 | 0.91 | 0.75 | 0.48 | 1.84 |
| Dom | 1.03 | 0.96 | 0.76 | 0.45 | 1.83 | |||
| Rec | 1.07 | 1.53 | 2.11 | – | – | |||