Summary of outcomes of pregnancies
| Clinical outcome | Exposed children | Non-exposed | Statistical significance | Test | Relative risk (95% CI) |
|---|---|---|---|---|---|
| *Only 242 facial photographs were available for review. | |||||
| †Data for major malformations include all pregnancies continuing into the second trimester. | |||||
| All other outcome categories include liveborn infants only. | |||||
| NS=not significant (p>0.05). | |||||
| Neonatal withdrawal | 50 | 1 | p=0.01 | χ2 | 7.45 (1.06-52.37) |
| Facial features present | 119/228* | 3/12* | p=0.086 (NS) | Cox's proportional hazards | 2.09 (0.78-5.61) |
| Congenital malformation (major) | 36/261† | 2 | p=0.193 (NS) | Fisher's exact (two tailed) | 2.62 (0.66-10.44) |
| Congenital malformation (minor) | 106 | 5 | p<0.001 | χ2 | 3.16 (1.38-7.24) |
| Childhood medical problems | 79 | 5 | p=0.001 | Cox's proportional hazards | 2.35 (1.02-5.44) |
| Developmental delay | 62 | 4 | p=0.01 | Cox's proportional hazards | 2.31 (0.89-5.98) |
| Behaviour disorders | 30 | 2 | p=0.056 (NS) | Cox's proportional hazards | 2.24 (0.56-8.98) |
| Major malformation or developmental delay | 80 | 5 | p=0.003 | Cox's proportional hazards | 2.38 (1.03-5.51) |
| Total liveborn children | 255 | 38 | |||