Table 2

Genetic polymorphisms and their allele frequencies, total number of cases and controls published, risk genotypes with their ORs and 95% confidence intervals, PAR, and sample size required to detect an association

PolymorphismsAllele frequencyCases*Controls*Risk G†OR95% CIPARSample size‡
*Cases and controls: all studies combined. †Risk G: risk genotype. ‡Sample size: the number of patients and controls required to detect an association, with power of 90% and a significance level of 0.0026 (correction for mutiple testing). §W: wild type. ¶V: variant allele.
Tp53
    Intron 30.176671981W§/V¶0.970.79-1.182900
V/V0.460.25-0.84
    Exon 40.365522219W/V1.080.88-1.132200
V/V0.700.51-0.95
    Intron 60.177332160W/V0.920.75-1.111500
V/V0.300.15-0.57
HRAS1 0.0820293252V carriers2.041.73-2.4114%430
L-myc 0.50593214W/V1.120.77-1.634000
V/V1.290.82-2.02
NAT1 0.24646796V carriers1.130.91-1.395%9100
NAT2
    Phenotype0.62476785V/V0.870.70-1.107400
    Genotype0.6116651809V/V0.990.87-1.131 410 000
GSTM1 0.7227762710V/V1.131.02-1.266%8900
GSTP1 0.32538397W/V1.190.91-1.5617%610
V/V2.151.30-3.56
GSTT1 0.4913241076V/V1.040.86-1.25117 000
CYP1A1
    m10.1513711241W/V0.990.83-1.1941 000
V/V1.200.78-1.86
    m20.117911468W/V1.180.94-1.488000
V/V0.930.51-1.69
    m30.0985178V carriers1.040.54-2.03150 000
    m40.03223221V carriers0.990.43-2.245 940 000
CYP1B1
    Codon 1190.14339361W/V1.621.15-2.29870
V/V0.600.11-3.31
    Codon 4320.66745747W/V0.840.61-1.172700
V/V1.090.79-1.50
    Codon 4530.14223223W/V0.960.62-1.4931 000
V/V1.240.33-4.71
CYP2D6
    Phenotype0.26335777V/V2.221.39-3.558%610
    Genotype0.188311165W/V1.190.97-1.456%4600
V/V1.260.81-1.96
CYP17 0.4027252531W/V0.990.88-1.1182 000
V/V1.050.89-1.23
CYP19
    TTTA repeat
        *10 allele0.0139343514V carriers1.591.01-2.481%6800
        *12 allele0.0239343514V carriers1.110.83-1.4977 000
    TCT intron 40.35599433W/V0.790.61-1.034500
V/V1.030.69-1.56
    Intron 60.48223164W/V1.150.72-1.853300
V/V1.330.77-2.29
    Codon 2640.30160125W/V0.830.50-1.354600
V/V0.910.38-2.14
ER
    PvuII0.5470453W/V0.840.40-1.7810 000
V/V0.930.41-2.13
    XbaI0.29191204W/V0.990.65-1.511200
V/V0.500.25-0.99
    Codon 3250.21646324W/V1.040.79-1.3827 000
V/V1.190.54-2.65
PR 0.141106965W/V0.950.78-1.162400
V/V0.320.16-0.65
COMT 0.4411661167W/V0.920.76-1.1018 000
V/V0.890.71-1.12
UGT1A1 0.34655808W/V0.990.80-1.24110 000
V/V1.050.75-1.47
HLA
    TNF-alpha0.2140106W/V3.491.62-7.5150%79
V/V4.800.28-81.1
    HSP70-20.4540106W/V1.740.55-5.5285%11
V/V27.54.30-176
    HSP70-hom0.2340106V carriers3.561.26-10.0123%84
VDR
    ApaI0.47135110W/V1.540.85-2.8038%290
V/V2.541.20-5.39
    BmsI0.35231467W/V1.160.83-1.6212%1900
V/V1.510.87-2.64
    FokI0.41278410W/V1.030.73-2.643%41 000
V/V1.090.69-1.73
    TaqI0.571197867W/V0.950.74-1.2061 000
V/V0.930.72-1.20
    Poly-A0.27143300W/V1.591.04-2.4242%310
V/V2.761.3-5.85
APOE 0.07260332E2 allele0.990.62-1.592 800 000
0.13E4 allele0.890.62-1.2614 000
EDH17B2 0.54190190W/V0.590.37-0.941500
V/V0.900.50-1.60
HER2 0.13339359W/V1.260.88-1.7920%110
V/V12.761.62-98.9
TBR-1 0.06152735W/V1.580.96-2.596%1400
TFR 0.40165294W/V1.010.66-1.554%7500
V/V1.200.70-2.05