TCP with diabetes (FCPD) | TCP without diabetes | Total | |
---|---|---|---|
WT=wild type. | |||
*One patient was found to be a compound heterozygote for N34S and P55S mutations. | |||
Number | 24 (17 M/7 F) | 44 (29 M/15 F) | 68 (46 M/22 F) |
Age at onset (median, range, 95% CI) | 35.0 y (27.6-40.2) | 21.0 y (19.9-27.1) | 24.0 y (23.8-30.5) |
Age at presentation (median, range, 95% CI) | 44.0 y (39.3-49.3) | 26.0 y (25.7-33.0) | 33.5 y (31.3-38.0) |
SPINK1 mutation | 12 | 20 | 32 |
Homozygous | 4 | 4 | 8 |
Heterozygous | 8 | 16 | 24 |
N34S/WT | 6 | 16 | 22 |
N34S/P55S* | 1 | – | 1 |
P55S/WT | 1 | – | 1 |