Exon | Genotype (polymorphism) | Amino acid change | No (%) of tumours with specific genotype (polymorphism)/No of tumours analysed | No (%) of tumours with specific genotype (polymorphism) and lymphoid infiltration | p* |
---|---|---|---|---|---|
NS=not significant. | |||||
*Using the χ2 test, the proportions of tumours with lymphoid infiltration were compared among different alleles within the same locus (exon). | |||||
†Polymorphism previously described by Stein et al.20 | |||||
‡Polymorphism previously described by Hoffmeyer et al.21 | |||||
§Polymorphism previously described by Mickley et al.22 | |||||
Promoter | †Promoter +8 T/T | 313/327 (96%) | 152/313 (49%) | ||
Promoter | Promoter +8 T/C | Non-coding | 14/327 (4%) | 9/14 (64%) | 0.036 |
Intron 1b | IVS1-81 (G)4 | 311/327 (95%) | 149/311 (48%) | ||
Intron 1b | IVS1-81 (G)4/(G)3 | Non-coding | 16/327 (5%) | 12/16 (75%) | 0.010 |
Intron 1b | ‡IVS-1 G/G | 271/317 (85%) | 127/271 (47%) | ||
Intron 1b | IVS-1 G/A | 45/317 (14%) | 27/45(60%) | NS | |
Intron 1b | IVS-1 A/A | Non-coding | 1/317 (<1%) | 1/1 (100%) | NS |
2 | ‡61 A/A | 266/321 (83%) | 125/266 (47%) | ||
2 | 61 A/G | Asn21Asp | 51/321 (16%) | 29/51 (57%) | NS |
2 | 61 G/G | 4/321 (1%) | 2/4 (50%) | NS | |
Intron 4 | ‡IVS4-25 G/G | 44/63 (70%) | 19/44 (43%) | ||
Intron 4 | IVS4-25 G/T | Non-coding | 15/63 (24%) | 7/15 (47%) | NS |
Intron 4 | IVS4-25 T/T | 4/63 (6%) | 2/4 (50%) | NS | |
11 | 1199 G/G | 307/327 (94%) | 152/307 (50%) | ||
11 | 1199 G/A | Ser400Asn | 20/327 (6%) | 11/20 (55%) | NS |
12 | ‡1236 C/C | 81/327 (25%) | 39/81 (48%) | ||
12 | 1236 C/T | No change | 163/327 (50%) | 80/163 (49%) | NS |
12 | 1236 T/T | 83/327 (25%) | 42/83 (51%) | NS | |
Intron 16 | IVS16+158 G/G | 82/87 (94%) | 41/82 (50%) | ||
Intron 16 | IVS16+158 G/A | Non-coding | 5/87 (6%) | 3/5 (60%) | NS |
21 | §2677 G/G | 14/41 (34%) | 7/14 (50%) | ||
21 | 2677 G/T | Ala893Ser | 17/41 (41%) | 7/17 (41%) | NS |
21 | 2677 T/T | 10/41 (24%) | 4 /10 (40%) | NS | |
26 | ‡3435 C/C | 44/159 (28%) | 18/44 (41%) | ||
26 | 3435 C/T | No change | 85/159 (53%) | 46/85 (54%) | NS |
26 | 3435 T/T | 30/159 (19%) | 15/30 (50%) | NS |