Genotype and allele frequencies in patients with CAD undergoing CABG (n=318) and in controls (n=248)
| Status | Genotype frequency 11/12/22* (%) | Allele 2 frequency (% (SE)) | |
|---|---|---|---|
| *2 represents the allele under consideration, 1 codes for all other alleles. | |||
| †Deviation from Hardy-Weinberg equilibrium (χ2=12.41, p=0.0004). The frequency of the homozygous carriers of the C4B*Q0 in CAD patients differs significantly from that of controls (p=0.02, odds ratio=3.8 (95% confidence interval 1.2–13.2). The frequency of the C4B*Q0 allele is different in cases and in controls (p=0.02, OR=1.5 (1.0–2.1)). | |||
| TNFα -238A | Cases | 90.2/9.8/0.0 | 4.9 (1.7) |
| Controls | 90.7/9.3/0.0 | 4.6 (1.8) | |
| TNFα -308A | Cases | 72.0/25.2/2.8 | 15.4 (2.9) |
| Controls | 72.9/26.2/0.9 | 13.9 (3.1) | |
| Bf*F | Cases | 64.2/31.4/4.4 | 20.4 (3.2) |
| Control | 69.5/27.3/3.2 | 17.0 (3.3) | |
| C4A*Q0 | Cases | 73.9/24.5/1.6 | 13.8 (2.7) |
| Controls | 70.9/27.4/1.7 | 15.6 (3.3) | |
| C4A*6 | Cases | 91.5/7.9/0.6 | 4.6 (1.7) |
| Controls | 95.6/4.4/0.0 | 2.2 (1.3) | |
| C4B*Q0 | Cases | 76.1/19.5/4.4† | 14.2 (2.8)† |
| Controls | 81.5/17.3/1.2 | 9.9 (2.7) | |