Table 1

Allele and genotype distribution of the −48 C/T polymorphism

		No		Allele distribution (%)			Genotype distribution (%)
		No		C	T		CC	CT	TT
Manchester population
AD cases	123	233 (0.95)	13 (0.05)		110 (0.89)	13 (0.11)	—
Control	117	213 (0.91)	21 (0.09)		97 (0.83)	19 (0.16)	1 (0.01)
Scottish population
AD cases	164	301 (0.92)	27 (0.08)		137 (0.84)	27 (0.16)	—
Control	365	649 (0.89)	81 (0.11)		290 (0.80)	69 (0.19)	6 (0.02)
Total population
AD cases	287	534 (0.93)^1-150	84 (0.07)		247 (0.86)^1-151	40 (0.14)	—
Control	482	862 (0.89)	102 (0.11)		387 (0.80)	88 (0.18)	7 (0.02)
Dutch population 12
AD cases	96	183 (0.95)^1-152	9 (0.05)		88 (0.92)^1-152	7 (0.07)	1 (0.01)
Control	117	209 (0.89)	25 (0.11)		94 (0.80)	21 (0.18)	2 (0.02)

↵1-150 p<0.01,
↵1-151 p<0.03,
↵1-152 p<0.04.
Number of subjects (frequency). No differences were detected in allele and genotype frequencies between UK centres. All genotype distributions were in Hardy-Weinberg equilibrium.