Comparison of the HOXA1 and HOXB1 allelic variants based on the clinical characteristics of the subjects with autism spectrum disorders (ASD)*
| HOXA1 | HOXB1 | |||||
|---|---|---|---|---|---|---|
| A/A | A/G | G/G | +/+ | +/INS | INS/INS | |
| *No statistical differences were identified between the allelic variants and the clinical data using an extension of Fisher’s exact test. | ||||||
| †Abnormal MRI seen in our subjects included encephalomalacia, atrophy of the optic chiasm, small periventricular white matter, and cerebellar hypoplasia. | ||||||
| Gender (n=35) | ||||||
| Male | 19 | 8 | 0 | 17 | 6 | 4 |
| Female | 5 | 2 | 1 | 5 | 3 | 0 |
| IQ (n=25) | ||||||
| <70 | 13 | 2 | 1 | 11 | 4 | 1 |
| ≥70 | 3 | 6 | 0 | 5 | 3 | 1 |
| MRI finding (n=20) | ||||||
| Abnormal† | 3 | 0 | 1 | 2 | 1 | 1 |
| Normal | 10 | 6 | 0 | 8 | 5 | 3 |
| EEG (n=16) | ||||||
| Abnormal | 4 | 1 | 0 | 2 | 1 | 2 |
| Normal | 5 | 5 | 1 | 7 | 2 | 2 |
| Seizures (n=34) | ||||||
| Yes | 6 | 1 | 1 | 3 | 4 | 1 |
| No | 17 | 9 | 0 | 18 | 5 | 3 |
| Language regression (n=33) | ||||||
| Yes | 7 | 5 | 1 | 11 | 2 | 0 |
| No | 15 | 5 | 0 | 10 | 6 | 4 |