Table 2

Cancers in eligible families

Family	LFL	Breast cancer	Osteosarcoma (age)	Other sarcoma	Other LFS spectrum cancers	Other cancers
Cancers are those in the sarcoma patient and breast cancer patient and in their first degree relatives.
Indicates subject tested. †Individual multiple primaries in a single person in a family (eg family 2252 contains a female with bilateral breast cancer aged 26 and 40 and a leiomyosarcoma aged 49 years); 45/50 indicates bilateral disease. ‡Indicates only family with proven TP53* germline mutation. Numbered families are those classified as LFL, which are also previously published.
729	Yes	42*, 52	Femur 9
2063	Yes	47/49*, 58	Femur 13
A	No	51*†	Femur 15	Ovary 59*†
B	No	42*†, 32		48		Cervix 35*†
C	No	34*†		Abdomen 66*†		BCC 67*†
D	No	55*		Fibrosarcoma 67		Colon 42, RCC 39
E	No	55*†	Femur 18			Melanoma 31*†
F	No	35*†	Radius 40*†
G	No	29*, 40†		Abdomen 45†
H	No	31*		Uterus 62
I	No	38*†	Femur 18*†
J	No	42*, 62	Humerus 2
K	No	45/54*†, 73		Synovial 27		Oesophagus 57*†
L	No	30, 44*†		Pelvis 55*†
M	No	39*†		Fibrosarcoma 33*†
N	No	37*†	Femur 15*†
2252‡	Yes	25, 26/40*†		Leiomyosarcoma buttock 49*†	Glioblastoma 15, PNET 10,	Abdominal malignancy 23
338	Yes	36/44*†		Chondrosarcoma 35*†	PNET 7
80	Yes	35*†, 29, 60		Liposarcoma 30*		Ovary 51, rectal 44
328	Yes	45	16*		Glioma 56
1799	Yes	37*†		Soft tissue 37*†		Stomach 48, 42