Distribution of polymorphic variants in exons 3 and 4 of the EPHX gene
| Gene | Variant | Pre-eclampsia without HELLP (n=87) | Pre-eclampsia with HELLP (n=96) | Pre-eclampsia, all (n=183) | Controls (n=151) | |
| Exon 3 | Tyr113 Tyr113 | 27 (31) | 24 (25) | 51 (28)2-150 | 24 (16)2-150 | |
| Tyr113 His113 | 22 (25) | 26 (27) | 48 (26) | 60 (40) | ||
| His113 His113 | 38 (44) | 46 (48) | 84 (46) | 67 (44) | ||
| Exon 4 | His139 His139 | 54 (62) | 49 (51) | 103 (56) | 96 (64) | |
| His139 Arg139 | 27(31) | 40 (42) | 67 (37) | 50 (33) | ||
| Arg139 Arg139 | 6 (7) | 7 (7) | 13 (7) | 5 (3) | ||
Assessment of genetic polymorphisms are described in Methods. Percentages are given in parentheses. Statistical significance of differences between patient and control group was assessed with the chi-square test.
EPHX, epoxide hydrolase; Tyr, tyrosine; His, histidine; Arg, arginine.
↵2-150 p<0.01 pre-eclampsia versus controls.