Positive predictive value and relative sensitivity of criteria on probands and relatives for predictive p53 screening in childhood cancer
| Criteria on proband | Criteria on relatives | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Very loose | Loose | Stringent | Very stringent | ||||||||||
| Predictive value | Relative sensitivity | Predictive value | Relative sensitivity | Predictive value | Relative sensitivity | Predictive value | Relative sensitivity | ||||||
| Any tumour | 6% (14/223) | 93% (14/15) | 9% (13/141) | 87% (13/15) | 15% (12/81) | 80% (12/15) | 43% (9/21) | 60% (9/15) | |||||
| Narrow spectrum | 12% (12/102) | 80% (12/15) | 16% (11/67) | 73% (11/15) | 23% (11/47) | 73% (11/15) | 53% (8/15) | 53% (8/15) | |||||