MBL genotype | Cirrhosis | Non-cirrhosis | % Cirrhosis |
p values (Fisher's exact test) | ||||
Wild type (NN) | ||||||||
n=131 (60.7%) | n=9 | n=122 | 6.9% | |||||
Heterozygotes (NM) | ||||||||
n=72 (33.3%) | n=2 | n=70 | 2.8% | NS^{1-150} | ||||
52/N n=18 | 1 | 17 | ||||||
54/N n=46 | 1 | 45 | ||||||
57/N n=8 | 0 | 8 | ||||||
Subtotal (NN+NM) | ||||||||
n=203 (94.0%) | n=11 | n=192 | 5.4% | 0.008^{1-151} | ||||
[OR: 7.76 | ||||||||
95% CI: 2.01–29.00] | ||||||||
Mutated homozygotes or compound heterozygotes (MM) | ||||||||
n=13 (6.0%) | n=4 | n=9 | 30.8% | 0.045^{1-150} | ||||
54/54 n=5 | 2 | 3 | (OR 6.02, | |||||
57/57 n=1 | 0 | 1 | 95% CI: 1.51–24.10) | |||||
52/54 n=6 | 2 | 4 | ||||||
54/57 n=1 | 0 | 1 | ||||||
Total | ||||||||
n=216 (100%) | n=15 | n=201 | 6.9% |
MBL: mannose binding lectin. NS: not significant. OR: odds ratio.
↵1-150 Compared to NN group.
↵1-151 Compared to MM group.
The mannose binding lectin genotype frequencies are in Hardy-Weinberg proportions for all the 216 patients. Sex ratio and mean age of the cirrhotic and the non-cirrhotic groups do not differ statistically. The frequency of the MBL mutated alleles is 0.33 and 0.22 in the cirrhotic and non-cirrhotic groups, respectively. This difference is not significant because the frequency of cirrhosis in the NM group is low, but not statistically different from that observed in the NN group. Nearly half of the population comes from adult centres.